There is abundant evidence that tumor-infiltrating CD8+ T cells contribute positively to
antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells …

Tertiary lymphoid structures (TLS) are ectopic cellular aggregates that resemble secondary
lymphoid organs in their composition and structural organization. In contrast to secondary …

Tumor associated inflammation predicts response to immune checkpoint blockade in human
melanoma. Current theories on regulation of inflammation center on anti-tumor T cell …

Background Treatment options for malignant pleural mesothelioma are scarce.
Tazemetostat, a selective oral enhancer of zeste homolog 2 (EZH2) inhibitor, has shown …

High numbers of tissue-resident memory T (TRM) cells are associated with better clinical
outcomes in cancer patients. However, the molecular characteristics that drive their efficient …

Over the past decade, immune-checkpoint inhibitors (ICIs) have revolutionized the treatment
of cancer. In mesothelioma, a rare cancer with a dismal prognosis generally caused by …

As targeted molecular therapies and immuno-oncology have become pivotal in the
management of patients with lung cancer, the essential requirement for high throughput …

In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …

Although mesothelioma is the consequence of a protracted immune response to asbestos
fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches …

LMB-100 is a recombinant immunotoxin composed of a Fab linked to a toxin. It kills cells
expressing human mesothelin (hMSLN), which is highly expressed on the surface of …