Abstract We previously reported Paired-Tag, a combinatorial indexing-based method that
can simultaneously map histone modifications and gene expression at single-cell resolution …

Increasing evidence suggests that transcriptional control and chromatin activities at large
involve regulatory RNAs, which likely enlist specific RNA-binding proteins (RBPs). Although …

RNA-binding proteins (RBPs) play crucial roles in almost all aspects of cellular biology. RBP
binding at specific target sites impacts expression of functionally coordinated sets of mRNAs …

An interplay of experimental and computational methods is required to achieve a
comprehensive understanding of protein–RNA interactions. UV crosslinking and …

The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …

Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …

Papillary thyroid carcinoma (PTC) is the main type of thyroid carcinoma. Despite the good
prognosis, some PTC patients may deteriorate into more aggressive diseases, leading to …

Summary Genomic amplification of 3q26. 2 locus leads to the increased expression of
microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results …

Circular RNAs (circRNAs), with their crucial roles in gene regulation and disease
development, have become rising stars in the RNA world. To understand the regulatory …

Abstract Motivation Long non-coding RNAs (lncRNAs) are defined as transcripts longer than
200 nt that do not get translated into proteins. Often these transcripts are processed (spliced …