The gut microbiome has emerged as a critical regulator of human physiology. Deleterious
changes to the composition or number of gut bacteria, commonly referred to as gut …

Bile acids (BA) are amphipathic steroid acids synthesized from cholesterol in the liver. They
act as detergents to expedite the digestion and absorption of dietary lipids and lipophilic …

Bile acids (BA), long believed to only have lipid-digestive functions, have emerged as novel
metabolic modulators. They have important endocrine effects through multiple cytoplasmic …

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

Despite advances in preventive measures and treatment options, cardiovascular disease
(CVD) remains the number one cause of death globally. Recent research has challenged …

Research over the last decade has uncovered roles for bile acids (BAs) that extend beyond
their traditional functions in regulating lipid digestion and cholesterol metabolism. BAs are …

Gallstones are one of the most common digestive diseases with an estimated prevalence of
10%‐15% in adults living in the western world, where cholesterol‐enriched gallstones …

The causes of obstructive jaundice are varied, but it is most commonly due to
choledocholithiasis; benign strictures of the biliary tract; pancreaticobiliary malignancies; …

The large Ca2+-activated K+ channel (BK channel) reflects per excellence the dilemma of
the molecular target driven drug discovery process. Significant experimental evidence …

The bile acid pool with its individual bile acids (BA) is modulated in the enterohepatic
circulation by the liver as the primary site of synthesis, the motility of the gallbladder and of …