Oxidative damage and the prevention of age-related cataracts

DC Beebe, NM Holekamp, YB Shui - Ophthalmic research, 2010 - karger.com
Purpose: Cataracts are often considered to be an unavoidable consequence of aging.
Oxidative damage is a major cause or consequence of cortical and nuclear cataracts, the …

Drug delivery to the lens for the management of cataracts

TR Thrimawithana, ID Rupenthal, SS Räsch… - Advanced drug delivery …, 2018 - Elsevier
Cataracts are one of the most prevalent diseases of the lens, affecting its transparency and
are the leading cause of reversible blindness in the world. The clarity of the lens is essential …

The spectral transmission of ocular media suggests ultraviolet sensitivity is widespread among mammals

RH Douglas, G Jeffery - … of the Royal Society B: Biological …, 2014 - royalsocietypublishing.org
Although ultraviolet (UV) sensitivity is widespread among animals it is considered rare in
mammals, being restricted to the few species that have a visual pigment maximally sensitive …

Optical density of the aging human ocular media in the visible and the UV

J Van De Kraats, D Van Norren - JOSA A, 2007 - opg.optica.org
We analyzed the literature on the absorption in the young and aging human eye media. Five
templates were derived to provide an adequate description of the spectra from 300 to 700 …

UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens …

M Linetsky, CT Raghavan, K Johar, X Fan… - Journal of Biological …, 2014 - ASBMB
Advanced glycation end products (AGEs) contribute to lens protein pigmentation and cross-
linking during aging and cataract formation. In vitro experiments have shown that ascorbate …

Incidence of ocular melanoma in Australia from 1990 to 1998

CM Vajdic, A Kricker, M Giblin… - … journal of cancer, 2003 - Wiley Online Library
Routinely collected incidence data have often lacked specific identification of ocular
melanoma in the past and with increasing diagnosis and management of this disease by …

Sun exposure predicts risk of ocular melanoma in Australia

CM Vajdic, A Kricker, M Giblin… - … journal of cancer, 2002 - Wiley Online Library
Previous studies examining sun exposure and ocular melanoma have produced
inconsistent results. We investigated this association in a population‐based case‐control …

[HTML][HTML] Age-related changes in the absorption characteristics of the primate lens

ER Gaillard, L Zheng, JC Merriam… - … ophthalmology & visual …, 2000 - arvojournals.org
purpose. To quantitate aging of the primate lens by changes in the absorption characteristics
that are related to the yellowing of lens protein. methods. The lenses of lower primates and …

Improved CoChR variants restore visual acuity and contrast sensitivity in a mouse model of blindness under ambient light conditions

TH Ganjawala, Q Lu, MD Fenner, GW Abrams, ZH Pan - Molecular Therapy, 2019 - cell.com
Severe photoreceptor cell death in retinal degenerative diseases leads to partial or
complete blindness. Optogenetics is a promising strategy to treat blindness. The feasibility of …

Spectral evaluation of eyeglass blocking efficiency of ultraviolet/high-energy visible blue light for ocular protection

SA Giannos, ER Kraft, LJ Lyons… - Optometry and Vision …, 2019 - journals.lww.com
PURPOSE Studies have linked exposure of high-energy visible blue light to effect and
damage on retinal epithelial cells, photoreceptors, and ganglion cells.“Blue light” is more …