Noninvasive diagnosis of fetal aneuploidy by sequencing

HMC Fan, SR Quake - US Patent 8,195,415, 2012 - Google Patents
Disclosed is a method to achieve digital quantification of DNA (ie, counting differences
between identical sequences) using direct shotgun sequencing followed by mapping to the …

Methods for the diagnosis of fetal abnormalities

R Kapur, M Toner, R Stoughton, D Shoemaker… - US Patent …, 2012 - Google Patents
The present invention relates to methods for detecting, enriching, and analyzing rare cells
that are present in the blood, eg fetal cells. The invention further features methods of …

Microfluidic device for cell separation and uses thereof

M Toner, G Truskey, R Kapur - US Patent 8,304,230, 2012 - Google Patents
Related US Application Data (62) Division of application No. 10/529,453, filed as application
No. PCT/US03/30965 on Sep. 29, 2003.(60) Provisional application No. 60/414,065, filed on …

Rare cell analysis using sample splitting and DNA tags

D Shoemaker, M Toner, R Kapur… - US Patent 8,372,584, 2013 - Google Patents
YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl) anilino] pyrimidin-4-yl]
amino] phenyl] cyclopropanecarboxamide Chemical compound FC (F)(F) C1= CC= CC …

Devices and methods for enrichment and alteration of cells and other particles

LR Huang, TA Barber, BL Carvalho, R Kapur… - US Patent …, 2011 - Google Patents
2011-08-15 Assigned to VERINATA HEALTH, INC reassignment VERINATA HEALTH, INC
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Increasing dynamic range for identifying multiple epitopes in cells

GP Nolan - US Patent 10,174,310, 2019 - Google Patents
the present invention relates in part to the detection, identification, and quantification of
individual target molecules in single cells of a complex cell population while retaining cell …

Methods of identifying multiple epitopes in cells

GP Nolan - US Patent 10,144,950, 2018 - Google Patents
US10144950B2 - Methods of identifying multiple epitopes in cells - Google Patents
US10144950B2 - Methods of identifying multiple epitopes in cells - Google Patents …

Fluidics devices

CE Clemens, R Mucic, RA Montalvo, C Foster… - US Patent …, 2011 - Google Patents
The following documents are all incorporated herein by reference in their entireties,
although none is admitted to be prior or relevant art. Collectively they reflect that there is a …

Microfluidic device for cell separation and uses thereof

M Toner, G Truskey, R Kapur - US Patent 8,372,579, 2013 - Google Patents
The invention features methods for separating cells from a sample (eg, separating fetal red
blood cells from maternal blood). The method begins With the introduction of a sample …

Laminar flow-based separations of colloidal and cellular particles

J Oakey, DWM Marr - US Patent 7,318,902, 2008 - Google Patents
A system, method and apparatus employing the laminar nature of fluid flows in microfluidic
flow devices in separating, sorting or filtering colloidal and/or cellular particles from a …