In this article, we review physics-based models of collective cell motility. We discuss a range
of techniques at different scales, ranging from models that represent cells as simple self …

Mathematical modeling is an essential approach for the understanding of complex
multicellular behaviors in tissue morphogenesis. Here, we review the cellular Potts model …

Many multicellular systems problems can only be understood by studying how cells move,
grow, divide, interact, and die. Tissue-scale dynamics emerge from systems of many …

In this paper we present an overview of agent-based models that are used to simulate
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …

The coordinated behaviour of populations of cells plays a central role in tissue growth and
renewal. Cells react to their microenvironment by modulating processes such as movement …

In this chapter we have presented mathematical modeling approaches to biological pattern
formation. While reaction-diffusion models are appropriate to describe the spatio-temporal …

Recent technological breakthroughs in our ability to derive and differentiate induced
pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all …

Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and
response to treatment of different cancer cell lines. Their popularity is largely due to the …

Over the past 25 years, there has been an unparalleled increase in understanding of cancer
biology. This transformation is exemplified by Hanahan and Weinberg's decision in 2011 to …

Severe COVID-19 patients present a clinical and laboratory overlap with other
hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH) …