Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and
Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i …

Molecular evolution offers an insightful theory to interpret the genomic consequences of
thermal adaptation to previous events of climate change beyond range shifts. However …

The human Y chromosome has been notoriously difficult to sequence and assemble
because of its complex repeat structure that includes long palindromes, tandem repeats and …

Repetitive genomic sequences can adopt a number of alternative DNA structures that differ
from the canonical B-form duplex (ie non-B DNA). These non-B DNA-forming sequences …

The non-B DB, available at http://nonb. abcc. ncifcrf. gov, catalogs predicted non-B DNA-
forming sequence motifs, including Z-DNA, G-quadruplex, A-phased repeats, inverted …

The importance of local DNA structures in the regulation of basic cellular processes is an
emerging field of research. Amongst local non-B DNA structures, G-quadruplexes are …

DNA cruciform structures play an important role in the regulation of natural processes
including gene replication and expression, as well as nucleosome structure and …

A prominent source of mutation in cancer is single-stranded DNA cytosine deamination by
cellular APOBEC3 enzymes, which results in signature C-to-T and C-to-G mutations in TCA …

How phenotypic diversity originates and persists within populations are classic puzzles in
evolutionary biology. While balanced polymorphisms segregate within many species, it …

Motivation Non-canonical (or non-B) DNA are genomic regions whose three-dimensional
conformation deviates from the canonical double helix. Non-B DNA play an important role in …