Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

Modern subunit vaccines: development, components, and research opportunities

PM Moyle, I Toth - ChemMedChem, 2013 - Wiley Online Library
Traditional vaccines, based on the administration of killed or attenuated microorganisms,
have proven to be among the most effective methods for disease prevention. Safety issues …

The challenge of emerging and re-emerging infectious diseases

DM Morens, GK Folkers, AS Fauci - Nature, 2004 - nature.com
Infectious diseases have for centuries ranked with wars and famine as major challenges to
human progress and survival. They remain among the leading causes of death and …

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

ST Reddy, AJ Van Der Vlies, E Simeoni, V Angeli… - Nature …, 2007 - nature.com
Abstract Antigen targeting,,,, and adjuvancy schemes, that respectively facilitate delivery of
antigen to dendritic cells and elicit their activation have been explored in vaccine …

Vaccines, adjuvants and autoimmunity

LE Guimarães, B Baker, C Perricone… - Pharmacological …, 2015 - Elsevier
Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host
immune response against an antigen can elicit a memory T-cell response over time …

Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants

X Li, R Xing, C Xu, S Liu, Y Qin, K Li, H Yu, P Li - Carbohydrate polymers, 2021 - Elsevier
Vaccines have always been the most effective preventive treatment. Advancements in the
field of vaccine is inseparable from adjuvants. Adjuvants are substances added to vaccines …

Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming

A Martín-Fontecha, LL Thomsen, S Brett, C Gerard… - Nature …, 2004 - nature.com
Naive T cells are stimulated by antigen-presenting dendritic cells (DCs) in secondary
lymphoid organs, but whether other types of cell participate in T cell priming is unclear. Here …

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses

MO Oyewumi, A Kumar, Z Cui - Expert review of vaccines, 2010 - Taylor & Francis
The development of novel immune adjuvants is emerging as a significant area of vaccine
delivery based on the continued necessity to amplify immune responses to a wide array of …

[HTML][HTML] Ginseng, the'immunity boost': the effects of Panax ginseng on immune system

S Kang, H Min - Journal of ginseng research, 2012 - ncbi.nlm.nih.gov
Thousands of literatures have described the diverse role of ginseng in physiological
processes such as cancer, neurodegenerative disorders, insulin resistance, and …

Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens

DS Watson, AN Endsley, L Huang - Vaccine, 2012 - Elsevier
Liposomes (phospholipid bilayer vesicles) are versatile and robust delivery systems for
induction of antibody and T lymphocyte responses to associated subunit antigens. In the last …