Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

The key role of mitochondrial function in health and disease

I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals

R Furrer, JA Hawley, C Handschin - Physiological Reviews, 2023 - journals.physiology.org
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

[HTML][HTML] Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures

YS Elhassan, K Kluckova, RS Fletcher, MS Schmidt… - Cell reports, 2019 - cell.com
Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress
and has been reported to decline with aging in preclinical models, but human data are …

Mitochondrial dysfunction: roles in skeletal muscle atrophy

X Chen, Y Ji, R Liu, X Zhu, K Wang, X Yang… - Journal of Translational …, 2023 - Springer
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Antioxidants and exercise performance: with a focus on vitamin E and C supplementation

MR Higgins, A Izadi, M Kaviani - International Journal of Environmental …, 2020 - mdpi.com
Antioxidant supplementation, including vitamin E and C supplementation, has recently
received recognition among athletes as a possible method for enhancing athletic …

Maintenance of skeletal muscle mitochondria in health, exercise, and aging

DA Hood, JM Memme, AN Oliveira… - Annual Review of …, 2019 - annualreviews.org
Mitochondria are critical organelles responsible for regulating the metabolic status of
skeletal muscle. These organelles exhibit remarkable plasticity by adapting their volume …

Physiological adaptations to interval training and the role of exercise intensity

MJ MacInnis, MJ Gibala - The Journal of physiology, 2017 - Wiley Online Library
Interval exercise typically involves repeated bouts of relatively intense exercise interspersed
by short periods of recovery. A common classification scheme subdivides this method into …

Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice

T Le Roy, EM de Hase, M Van Hul, A Paquot… - Gut, 2022 - gut.bmj.com
Objective To investigate the abundance and the prevalence of Dysosmobacter welbionis
J115T, a novel butyrate-producing bacterium isolated from the human gut both in the …