The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …

Post-translational modifications (PTMs) produce significant changes in the structural
properties of intrinsically disordered proteins (IDPs) by affecting their energy landscapes …

Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …

Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

The estrogen receptor (ER) mediates most of the biological effects of estrogens at the level
of gene regulation by interacting through its site‐specific DNA and with other coregulatory …

Gene-specific transcription factors (TFs) are key regulatory components of signaling
pathways, controlling, for example, cell growth, development, and stress responses. Their …

Nuclear receptors (NRs) regulate and coordinate multiple processes by integrating internal
and external signals, thereby maintaining homeostasis in front of nutritional, behavioral and …

Glucocorticoid receptor (GR) binds to genomic response elements and regulates gene
transcription with cell and gene specificity. Within a response element, the precise sequence …

Glucocorticoid hormones (GC) regulate essential physiological functions including energy
homeostasis, embryonic and postembryonic development, and the stress response. From …

Breast cancer is the second most leading cause of death among women. Multiple drugs
have been approved by FDA for the treatment of BC. The major drawbacks of existing drugs …