The human gastrointestinal tract (GI) harbors a diverse population of microbial life that
continually shapes host pathophysiological responses. Despite readily available abundant …

Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

Pectins are a part of daily diet as well as food additives that are indigestible polysaccharides
by human enzymes, however, they can be easily degraded by gut bacteria with the …

Healing of the inflamed mucosa (mucosal healing) is an emerging new goal for therapy and
predicts clinical remission and resection-free survival in inflammatory bowel diseases …

Differential alteration of Toll-like receptor (TLR) expression in inflammatory bowel disease
(IBD) was first described 10 years ago. Since then, studies from many groups have led to the …

Consumption of fermented milk (FM) containing a probiotic, Lactobacillus gasseri SBT2055
(LG2055), previously showed a reduction in abdominal adiposity in a randomised controlled …

The intestinal epithelial cells (IECs) form a selective permeability barrier separating luminal
content from underlying tissues. Upon injury, the intestinal epithelium undergoes a wound …

The mucosal surfaces of the gastrointestinal tract are continually exposed to an enormous
antigenic load of microbial and dietary origin, yet homeostasis is maintained. Pattern …

Whether metabolites derived from injured renal tubular epithelial cells (TECs) participate in
renal fibrosis is poorly explored. After TEC injury, various metabolites are released and …

Objective Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated
cytokine network, but novel therapeutic principles are urgently needed. Here we identify the …