Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

The liver is the only internal human organ capable of natural regeneration of lost tissue, as
little as 25% of a liver can regenerate into a whole liver. The process of aging predisposes to …

Experimental studies reported biochemical actions underpinning aging processes and
mortality, but the relevant metabolic alterations in humans are not well understood. Here we …

Cellular senescence can modulate various pathologies and is associated with irreparable
DNA double-strand breaks (IrrDSBs). Extracellular senescence metabolomes (ESMs) were …

Metabolomics is the latest state-of-the-art omics technology that provides a comprehensive
quantitative profile of metabolites. The metabolites are the cellular end products of metabolic …

Metabolomics is the latest 'omics' technology and systems biology science that allows for
comprehensive profiling of small-molecule metabolites in biological systems at a specific …

Dietary restriction (DR), a moderate reduction in food intake, improves health during aging
and extends life span across multiple species. Specific nutrients, rather than overall calories …

Coronary heart disease is one of the main causes of death in the developed world, and
treatment success remains modest, with high mortality rates within 1 year after myocardial …

The interplay between microbiota and host metabolism plays an important role in health.
Here, we examined the relationship between age, gut microbiome and host serum …

Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common
pathogenic background. Perturbations in protein/amino acid metabolism may play a role in …