Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Fibronectin structure and composition regulate contextual cell signaling. Recent advances
have been made in understanding fibronectin and its role in tissue organization and repair …

Spinal cord injury in mammals is thought to trigger scar formation with little regeneration of
axons,,–. Here we show that a crush injury to the spinal cord in neonatal mice leads to scar …

Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis,
mainly due to delayed detection. We hypothesized that intercellular communication is critical …

The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

The ability of skin to act as a barrier is primarily determined by cells that maintain the
continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult …

The fibrotic encapsulation of implants involves the mechanical activation of myofibroblasts
and of pro-fibrotic transforming growth factor beta 1 (TGF-β1). Here, we show that both …

Fibronectin (FN) is a ubiquitous extracellular matrix (ECM) glycoprotein that plays vital roles
during tissue repair. The plasma form of FN circulates in the blood, and upon tissue injury, is …

The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle
for tissue repair in central nervous system (CNS). Here we report that injection of imidazole …

Age-related changes in the niche have long been postulated to impair the function of
somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle …