Metallo-β-lactamases: structure, function, epidemiology, treatment options, and the development pipeline

SE Boyd, DM Livermore, DC Hooper… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae

L Xu, X Sun, X Ma - Annals of clinical microbiology and antimicrobials, 2017 - Springer
Purpose Carbapenem resistant K. pneumoniae (CRKP) has aroused widespread attention
owing to its very limited therapeutic options, and this strain has increased rapidly in recent …

A systematic review and meta-analyses of the clinical epidemiology of carbapenem-resistant Enterobacteriaceae

K van Loon, AF Voor in 't holt… - Antimicrobial agents and …, 2018 - Am Soc Microbiol
Carbapenem-resistant Enterobacteriaceae (CRE) are major health care-associated
pathogens and responsible for hospital outbreaks worldwide. To prevent a further increase …

Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infection: A Meta-Analysis

P Liu, X Li, M Luo, X Xu, K Su, S Chen… - Microbial drug …, 2018 - liebertpub.com
Aims: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection has been rapidly
emerging as a life-threatening nosocomial disease in many countries. However, studies on …

Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations

JM Aguado, JT Silva, M Fernández-Ruiz… - Transplantation …, 2018 - Elsevier
Solid organ transplant (SOT) recipients are especially at risk of developing infections by
multidrug resistant (MDR) Gram-negative bacilli (GNB), as they are frequently exposed to …

Carbapenem-resistant Enterobacteriaceae in special populations: solid organ transplant recipients, stem cell transplant recipients, and patients with hematologic …

SM Pouch, MJ Satlin - Virulence, 2017 - Taylor & Francis
Carbapenem-resistant Enterobacteriaceae (CRE) are a major global public health concern
and pose a serious threat to immunocompromised hosts, particularly patients with …

Mortality due to KPC carbapenemase-producing Klebsiella pneumoniae infections: systematic review and meta-analysis: mortality due to KPC Klebsiella pneumoniae …

JA Ramos-Castañeda, A Ruano-Ravina… - Journal of Infection, 2018 - Elsevier
Introduction KPC carbapenemase-producing Klebsiella pneumoniae (KPC-KP) has become
a major public health challenge. Accordingly, this study sought to use a systematic review of …

Risk Factors for Carbapenem-resistant Klebsiella pneumoniae Infection and Mortality of Klebsiella pneumoniae Infection

Z Wang, RR Qin, L Huang, LY Sun - Chinese medical journal, 2018 - mednexus.org
Background: Klebsiella pneumoniae (KP) is a pathogen commonly causing nosocomial
infection. Carbapenem-resistant KP (CRKP) is more resistant to multiple antimicrobial drugs …

A systematic review of the effect of delayed appropriate antibiotic treatment on the outcomes of patients with severe bacterial infections

EJ Zasowski, M Bassetti, F Blasi, H Goossens, J Rello… - Chest, 2020 - Elsevier
Background Patients with severe bacterial infections often experience delay in receiving
appropriate treatment. Consolidated evidence of the impact of delayed appropriate …

Bloodstream infections after solid-organ transplantation

A Kritikos, O Manuel - Virulence, 2016 - Taylor & Francis
abstract Solid-organ transplantation (SOT) has become the preferred strategy to treat a
number of end-stage organ disease, because a continuous improvement in survival and …