Retinal vasculature development in health and disease

S Selvam, T Kumar, M Fruttiger - Progress in retinal and eye research, 2018 - Elsevier
Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Signal transduction by vascular endothelial growth factor receptors

S Koch, L Claesson-Welsh - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Vascular endothelial growth factors (VEGFs) are master regulators of vascular development
and of blood and lymphatic vessel function during health and disease in the adult. It is …

Signal transduction by vascular endothelial growth factor receptors

S Koch, S Tugues, X Li, L Gualandi… - Biochemical …, 2011 - portlandpress.com
VEGFs (vascular endothelial growth factors) control vascular development during
embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There …

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

L Jakobsson, CA Franco, K Bentley, RT Collins… - Nature cell …, 2010 - nature.com
Sprouting angiogenesis requires the coordinated behaviour of endothelial cells, regulated
by Notch and vascular endothelial growth factor receptor (VEGFR) signalling. Here, we use …

Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1

HM Eilken, R Diéguez-Hurtado, I Schmidt… - Nature …, 2017 - nature.com
Pericytes adhere to the abluminal surface of endothelial tubules and are required for the
formation of stable vascular networks. Defective endothelial cell-pericyte interactions are …

[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation

A Uemura, M Fruttiger, PA d'Amore, S De Falco… - Progress in retinal and …, 2021 - Elsevier
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …

Angiogenesis: a team effort coordinated by notch

LK Phng, H Gerhardt - Developmental cell, 2009 - cell.com
The past two decades of angiogenesis research have identified a wealth of pro-and
antiangiogenic signals originating from the tissue environment, which control blood vessel …

Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning

P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

[HTML][HTML] Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

M Mazzone, D Dettori, RL de Oliveira, S Loges… - Cell, 2009 - cell.com
A key function of blood vessels, to supply oxygen, is impaired in tumors because of
abnormalities in their endothelial lining. PHD proteins serve as oxygen sensors and may …

The janus face of VEGF in stroke

SJ Geiseler, C Morland - International journal of molecular sciences, 2018 - mdpi.com
The family of vascular endothelial growth factors (VEGFs) are known for their regulation of
vascularization. In the brain, VEGFs are important regulators of angiogenesis …