Umbilical cord blood transplantation: Still growing and improving

X Zhu, B Tang, Z Sun - Stem cells translational medicine, 2021 - academic.oup.com
Umbilical cord blood transplantation (UCBT) has been performed in the clinic for over 30
years. The biological and immunological characteristics of umbilical cord blood (UCB) have …

[HTML][HTML] Guidelines for the prevention and management of graft-versus-host disease after cord blood transplantation

DM Ponce, I Politikos, A Alousi, PA Carpenter… - … and Cellular Therapy, 2021 - Elsevier
The incidence of graft-versus-host disease (GVHD) after cord blood (CB) transplantation
(CBT) is lower than expected given the marked degree of human leukocyte antigen (HLA) …

Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation

M Ogata, K Oshima, T Ikebe, K Takano… - Bone marrow …, 2017 - nature.com
In this retrospective analysis using the Transplant Registry Unified Management Program,
we identified 145 patients with human herpesvirus (HHV)-6 encephalitis among 6593 …

[HTML][HTML] Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes

L Chang, D Frame, T Braun, E Gatza… - Biology of Blood and …, 2014 - Elsevier
Engraftment syndrome (ES), characterized by fever, rash, pulmonary edema, weight gain,
liver and renal dysfunction, and/or encephalopathy, occurs at the time of neutrophil recovery …

Single cord blood transplantation versus unmanipulated haploidentical transplantation for adults with acute myeloid leukemia in complete remission

T Konuma, J Kanda, S Yamasaki, K Harada… - … and Cellular Therapy, 2021 - Elsevier
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative post-remission
therapy for adult patients with acute myeloid leukemia (AML) in complete remission (CR) …

High incidence of haemophagocytic syndrome following umbilical cord blood transplantation for adults

S Takagi, K Masuoka, N Uchida… - British journal of …, 2009 - Wiley Online Library
Umbilical cord blood transplantation (CBT) is widely accepted, but one critical issue for adult
patients is a low engraftment rate, of which one cause is haemophagocytic syndrome (HPS) …

[HTML][HTML] A novel reduced-toxicity myeloablative conditioning regimen using full-dose busulfan, fludarabine, and melphalan for single cord blood transplantation …

H Yamamoto, N Uchida, M Yuasa, K Kageyama… - Biology of Blood and …, 2016 - Elsevier
A pilot study of a novel, reduced-toxicity, myeloablative conditioning regimen using
intravenous busulfan 12.8 mg/kg, fludarabine 180 mg/m 2, and melphalan 80 mg/m 2 for …

[PDF][PDF] Downstream bioprocessing of AAV vectors: industrial challenges & regulatory requirements

M Hebben - Cell Gene Ther. Insights, 2018 - cdn.insights.bio
PURPOSE & CHALLENGES OF AAV DOWNSTREAM PROCESSING The purpose of
downstream processing is to purify the active ingredient from the upstream process-derived …

Single cord blood transplantation in Japan; expanding the possibilities of CBT

H Yamamoto - International Journal of Hematology, 2019 - Springer
Cord blood (CB) has been an alternative stem cell source for patients with a wide variety of
hematological diseases. Cord blood confers the advantages of rapid availability and higher …

Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutically limit pathology in patients

L Jin, Z Sun, H Liu, X Zhu, Y Zhou, B Fu… - Nature …, 2021 - nature.com
Unrelated cord blood transplantation (UCBT) is an effective treatment for hematopoietic
disorders. However, this attractive approach is frequently accompanied by pre-engraftment …