Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

M Sadarangani, A Marchant… - Nature Reviews …, 2021 - nature.com
Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including …

Evaluation of the safety profile of COVID-19 vaccines: a rapid review

Q Wu, MZ Dudley, X Chen, X Bai, K Dong, T Zhuang… - BMC medicine, 2021 - Springer
Background The rapid process of research and development and lack of follow-up time post-
vaccination aroused great public concern about the safety profile of COVID-19 vaccine …

[HTML][HTML] Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase …

MD Tanriover, HL Doğanay, M Akova, HR Güner… - The Lancet, 2021 - thelancet.com
Background CoronaVac, an inactivated whole-virion SARS-CoV-2 vaccine, has been shown
to be well tolerated with a good safety profile in individuals aged 18 years and older in …

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

DS Khoury, D Cromer, A Reynaldi, TE Schlub… - Nature medicine, 2021 - nature.com
Predictive models of immune protection from COVID-19 are urgently needed to identify
correlates of protection to assist in the future deployment of vaccines. To address this, we …

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy children and adolescents: a double-blind, randomised …

B Han, Y Song, C Li, W Yang, Q Ma, Z Jiang… - The Lancet Infectious …, 2021 - thelancet.com
Background A vaccine against SARS-CoV-2 for children and adolescents will play an
important role in curbing the COVID-19 pandemic. Here we aimed to assess the safety …

Accelerated COVID-19 vaccine development: milestones, lessons, and prospects

K Bok, S Sitar, BS Graham, JR Mascola - Immunity, 2021 - cell.com
The development of effective vaccines to combat infectious diseases is a complex multi-year
and multi-stakeholder process. To accelerate the development of vaccines for coronavirus …

Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action

FX Heinz, K Stiasny - npj Vaccines, 2021 - nature.com
COVID-19 vaccines were developed with an unprecedented pace since the beginning of the
pandemic. Several of them have reached market authorization and mass production …

Covid‐19 vaccines and variants of concern: a review

I Hadj Hassine - Reviews in medical virology, 2022 - Wiley Online Library
Since the outbreak of coronavirus disease 2019 (Covid‐19) in December 2019, caused by
the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the number of …

[HTML][HTML] Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled …

R Ella, S Reddy, W Blackwelder, V Potdar, P Yadav… - The Lancet, 2021 - thelancet.com
Background We report the clinical efficacy against COVID-19 infection of BBV152, a whole
virion inactivated SARS-CoV-2 vaccine formulated with a toll-like receptor 7/8 agonist …

Neutralization of variant under investigation B. 1.617. 1 with sera of BBV152 vaccinees

PD Yadav, GN Sapkal, P Abraham… - Clinical Infectious …, 2022 - academic.oup.com
To the Editor—The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants in places where the virus is uncontained poses a global threat from the …