In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Nuclear magnetic resonance (NMR) spectroscopy is a well-established method for
analyzing protein structure, interaction, and dynamics at atomic resolution and in various …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

In-cell NMR spectroscopy provides precious structural and functional information on
biological macromolecules in their native cellular environment at atomic resolution …

NMR spectroscopy is a versatile tool for studying time-dependent processes: chemical
reactions, phase transitions or macromolecular structure changes. However, time-resolved …

In-cell NMR can investigate protein conformational changes at atomic resolution, such as
those changes induced by drug binding or chemical modifications, directly in living human …

Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for investigating cellular
structures and their compositions. While in vivo and whole-cell NMR have a long tradition in …

Background: Because of the interplay between mitochondrial respiration and cellular
metabolism, the simultaneous monitoring of both cellular processes provides important …

In-cell NMR, ie, NMR spectroscopy applied to studying specific macromolecules within living
cells, is becoming the technique of choice for the structural and mechanistic description of …