A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2,
CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central …

The implementation of next‐generation sequencing technologies has provided a sharp
picture of the genetic variability in the components and regulators of the alternative pathway …

Complement factor H-related proteins (FHRs) are strongly associated with different diseases
involving complement dysregulation, which suggests a major role for these proteins …

The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

Age-related macular degeneration (AMD) is a complex, multifactorial, progressive retinal
disease that affects millions of people worldwide and has become the leading cause of …

Hemolytic uremic syndrome (HUS) is a rare, life-threatening disease characterized by
thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. The atypical …

Complement is a key component of immune defence against infection; it potently drives
inflammation at sites of pathology and is essential for killing of pathogens. Genetic linkage of …

During the last decade, numerous studies have associated genetic variations in complement
components and regulators with a number of chronic and infectious diseases. The functional …

Age-related macular degeneration (AMD) is a common condition among the elderly
population that leads to the progressive central vision loss and serious compromise of …