Duchenne muscular dystrophy (DMD) is an X-linked, muscle wasting disease that affects 1
in 5000 males. Affected individuals become wheelchair bound by the age of twelve and …

ABSTRACT RNA-based therapeutics have entered the mainstream with seemingly limitless
possibilities to treat all categories of neurological disease. Here, common RNA-based drug …

Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …

Ca2+-regulated contractility is a key determinant of the quality of muscles. The sarcomeric
myofilament proteins are essential players in the contraction of striated muscles. The …

Congenital myopathies are rare and severe genetic diseases affecting the skeletal muscle
function in children and adults. They present a variable spectrum of phenotypes and a …

Introduction It is established that the exon-skipping approach can restore dystrophin in
Duchenne muscular dystrophy (DMD) patients. However, dystrophin restoration levels are …

Duchenne muscular dystrophy (DMD) is a devastating disease that results in life-limiting
complications such as loss of skeletal muscle function as well as respiratory and cardiac …

Given decades of neuroinflammatory pain research focused only on males, there is an
urgent need to better understand neuroinflammatory pain in females. This, paired with the …

Troponin I (TnI) regulates thin filament activation and muscle contraction. Two isoforms, TnI-
fast (TNNI2) and TnI-slow (TNNI1), are predominantly expressed in fast-and slow-twitch …

The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated
muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of …