RNA binding proteins that act at the post-transcriptional level display a richness of
mechanisms to modulate the transcriptional output and respond to changing cellular …

RNA network control is a key aspect of proper cellular homeostasis. In this context, RNA-
binding proteins (RBPs) play a major role as regulators of the RNA life cycle due to their …

Oncolytic virotherapy holds promise for cancer treatment, but the factors determining its
oncolytic activity remain unclear. Neutrophil extracellular traps (NETs) are associated with …

Highlights•MK endomitosis is associated with both a defect in cytokinesis and
karyokinesis.•A myosin II accumulation defect at the furrow induces the cytokinesis …

Nearly 7.5% of all human protein-coding genes have been assigned to the class of RNA-
binding proteins (RBPs), and over the past decade, RBPs have been increasingly …

Background Recent clinical studies have shown that transfusions of adult platelets increase
morbidity and mortality in preterm infants. Neonatal platelets are hyporesponsive to agonist …

Background Cellular RNA-binding proteins (RBPs) have multiple roles in post-
transcriptional control, and some are shown to bind DNA. However, the global localization …

Fetal and neonatal megakaryocyte progenitors are hyperproliferative compared with adult
progenitors and generate a large number of small, low-ploidy megakaryocytes. Historically …

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3/IMP3/KOC), initially identified
as an RNA-binding protein, is highly expressed in embryonic tissues and a variety of …

Mammal megakaryocytes (MK) undergo polyploidization during their differentiation. This
process leads to a marked increase in the MK size and of their cytoplasm. Contrary to …