The nucleophilic addition of carbon nucleophiles to amides has traditionally been a difficult
task, both due to reactivity and selectivity problems. When successful, these processes …

The use of simple and low-cost chromium chloride salts as catalysts or precatalysts for the
development of cost-effective methods is of significant synthetic and mechanistic interest …

Despite the preliminary success of transition metal‐catalyzed [3+ 2] annulation of amides
with olefins, the corresponding radical‐type [3+ 2] annulation remains a laborious challenge …

Carbon–carbon bond formation by metal-free cross-coupling of two reactants with low
reactivity represents a challenge in organic synthesis. Secondary amides and alkenes are …

The synthesis of aromatic ketones by chromium-catalyzed Kumada arylation of secondary
amides with organomagnesium reagents is described. This reaction was enabled by using …

Amides are a class of highly stable and readily available compounds. The amide functional
group constitutes a class of powerful directing/activating and protecting group for C C bond …

Ten types of Tf2O/TTBP-mediated amide transformation reactions were investigated. The
results showed that compared with pyridine derivatives 2, 6-di-tert-butyl-4-methylpyridine …

A one-pot reaction for the transformation of common secondary amides into amines with C–
C bond formation is described. This method consists of in situ amide activation with Tf2O …

The combination of amide activation by Tf2O with B (C6F5) 3-catalyzed hydrosilylation with
TMDS constitutes a method for the one-pot reduction of secondary amides to amines under …

Although the asymmetric catalysis has made a spurt of progress, the use of chiral auxiliaries
remains crucial in asymmetric synthesis due to both the reliability and versatility of the …