Targeted nuclear medicine. Seek and destroy
VM Tolmachev, VI Chernov… - Russian Chemical …, 2022 - iopscience.iop.org
The targeted delivery of radionuclides to tumours holds great promise for diagnosis and
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer
V Tolmachev, A Orlova, J Sörensen - Seminars in cancer biology, 2021 - Elsevier
Targeting of human epidermal growth factor type 2 (HER2) using monoclonal antibodies,
antibody-drug conjugates and tyrosine kinase inhibitors extends survival of patients with …
antibody-drug conjugates and tyrosine kinase inhibitors extends survival of patients with …
Imaging using radiolabelled targeted proteins: Radioimmunodetection and beyond
The use of radiolabelled antibodies was proposed in 1970s for staging of malignant
tumours. Intensive research established chemistry for radiolabelling of proteins and …
tumours. Intensive research established chemistry for radiolabelling of proteins and …
Comparative evaluation of engineered polypeptide scaffolds in HER2-targeting magnetic nanocarrier delivery
Targeted drug delivery is one of the most intriguing and challenging issues in modern
biomedicine. For active targeting, full-size IgG molecules (150 kDa) are usually used …
biomedicine. For active targeting, full-size IgG molecules (150 kDa) are usually used …
Technetium (I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect
GV Sidorenko, AE Miroslavov, MY Tyupina - Coordination Chemistry …, 2023 - Elsevier
Studies concerning the development of radiopharmaceuticals based on the Tc (I) carbonyl
core are considered from the coordination-chemical viewpoint. The coordination behavior of …
core are considered from the coordination-chemical viewpoint. The coordination behavior of …
Optimal composition and position of histidine-containing tags improves biodistribution of 99mTc-labeled DARPin G3
A Vorobyeva, A Schulga, E Konovalova, R Güler… - Scientific Reports, 2019 - nature.com
Radionuclide molecular imaging of HER2 expression in disseminated cancer enables
stratification of patients for HER2-targeted therapies. DARPin G3, a small (14 kDa) …
stratification of patients for HER2-targeted therapies. DARPin G3, a small (14 kDa) …
PET and SPECT imaging of the EGFR family (RTK class I) in oncology
The human epidermal growth factor receptor family (EGFR-family, other designations: HER
family, RTK Class I) is strongly linked to oncogenic transformation. Its members are …
family, RTK Class I) is strongly linked to oncogenic transformation. Its members are …
Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step …
Therapy for aggressive metastatic breast cancer remains a great challenge for modern
biomedicine. Biocompatible polymer nanoparticles have been successfully used in clinic …
biomedicine. Biocompatible polymer nanoparticles have been successfully used in clinic …
New phenothiazine conjugates as apoptosis inducing agents: Design, synthesis, In-vitro anti-cancer screening and 131I-radiolabeling for in-vivo evaluation
Phenothiazines (PTZs) are a group of compounds characterized by the presence of the 10H-
dibenzo-[b, e]-1, 4-thiazine system. PTZs used in clinics as antipsychotic drugs with other …
dibenzo-[b, e]-1, 4-thiazine system. PTZs used in clinics as antipsychotic drugs with other …
Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic …
RD Houvast, N Badr, T March, LDAN de Muynck… - European Journal of …, 2024 - Springer
Purpose Fluorescence-guided surgery (FGS) can play a key role in improving radical
resection rates by assisting surgeons to gain adequate visualization of malignant tissue …
resection rates by assisting surgeons to gain adequate visualization of malignant tissue …