Live attenuated vaccines against human viral diseases have been amongst the most
successful cost effective interventions in medical history. Smallpox was declared eradicated …

Tick-borne encephalitis (TBE) is one of the most dangerous human infections occurring in
Europe and many parts of Asia. The etiological agent Tick-borne encephalitis virus (TBEV) …

Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by
the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host …

Yellow fever (YF) is a viral disease, endemic to tropical regions of Africa and the Americas.
YF principally affects humans and nonhuman primates, and is transmitted via the bite of …

Yellow fever, a mosquito-borne viral hemorrhagic fever, is one of the most lethal diseases of
humankind. The etiologic agent is the prototype member of the genus Flavivirus, family …

Dengue viruses (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV) are
major global health and growing medical problems. While a live-attenuated vaccine exists …

To successfully establish infection, flaviviruses have to overcome the antiviral state induced
by type I interferon (IFN-I). The nonstructural NS5 proteins of several flaviviruses antagonize …

Studies of flavivirus virulence have focussed on variants with differing neurovirulence or
neuroinvasiveness in animal models, with the majority based on determining the …

Most areas of the globe are endemic for at least one flavivirus, putting billions at risk for
infection. This diverse group of viral pathogens causes a range of manifestations in humans …

Tick-borne encephalitis (TBE), one of the most dangerous neuroinfections in Europe and
Asia, is caused by tick-borne encephalitis virus (TBEV) and currently involves approximately …