The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

BACKGROUND Two developments in distinct fields are converging to create interest in
discovering small molecules from the human microbiome. First, the use of genomics to guide …

Mycolic acids are major and specific lipid components of the mycobacterial cell envelope
and are essential for the survival of members of the genus Mycobacterium that contains the …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

The spread of antimicrobial-resistant pathogens typically existing in biofilm formation and
the recent COVID-19 pandemic, although unrelated phenomena, have demonstrated the …

The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …

Human T cell antigen receptors (TCRs) pair in millions of combinations to create complex
and unique T cell repertoires for each person. Through the use of tetramers to analyze TCRs …

CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one-third
of the world's population and causes 1.5 million deaths each year. The cell envelopes of …