Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …

Metabolic pathways are complex and intertwined. Deficiencies in one or more enzymes in a
given pathway are directly linked with genetic diseases, most of them having devastating …

Genome-wide association studies (GWASs) have identified genetic loci associated with the
risk of Alzheimer's disease (AD), but the molecular mechanisms by which they confer risk …

Accumulating evidences reveal that cellular cholesterol deficiency could trigger the onset of
Alzheimer's disease (AD). As a key regulator, 24-dehydrocholesterol reductase (DHCR24) …

Aims Sphingomyelin is an abundant component of the presynaptic membrane and an
organizer of lipid rafts. In several pathological conditions, sphingomyelin is hydrolyzed due …

The presence of insoluble aggregates of amyloid β (Aβ) in the form of neuritic plaques (NPs)
is one of the main features that define Alzheimer's disease. Studies have suggested that the …

Gaining insights into the intercellular receptor-ligand binding is of great importance for
understanding numerous physiological and pathological processes, and stimulating new …

Amyotrophic Lateral Sclerosis (ALS), Spinal Bulbar Muscular Atrophy (SBMA), and Spinal
Muscular Atrophy (SMA) are motor neuron diseases (MNDs) characterised by progressive …

The connexin gene family is the most prevalent gene that contributes to hearing loss.
Connexins 26 and 30, encoded by GJB2 and GJB6, respectively, are the most abundantly …

BACKGROUND: It has been established that sphingomyelin present human breast milk is
useful for the brain maturation and cognitive development. At 10 days of breastfeeding the …