Polyphenols and their impact on the prevention of neurodegenerative diseases and development

I Grabska-Kobyłecka, P Szpakowski, A Król… - Nutrients, 2023 - mdpi.com
It is well known that neurodegenerative diseases' development and progression are
accelerated due to oxidative stress and inflammation, which result in impairment of …

Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation

A Ashok, SS Andrabi, S Mansoor, Y Kuang, BK Kwon… - Antioxidants, 2022 - mdpi.com
Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles

A Bardestani, S Ebrahimpour, A Esmaeili… - Journal of …, 2021 - Springer
Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver
therapeutic molecules in the central nervous system (CNS). However, IONPs may damage …

Neurotoxic effects of heavy metal pollutants in the environment: Focusing on epigenetic mechanisms

G Yu, L Wu, Q Su, X Ji, J Zhou, S Wu, Y Tang… - Environmental Pollution, 2024 - Elsevier
The pollution of heavy metals (HMs) in the environment is a significant global environmental
issue, characterized by its extensive distribution, severe contamination, and profound …

Benefits and limitations of nanomedicine treatment of brain cancers and age-dependent neurodegenerative disorders

ME Neganova, YR Aleksandrova… - Seminars in Cancer …, 2022 - Elsevier
The treatment of central nervous system (CNS) malignancies, including brain cancers, is
limited by a number of obstructions, including the blood-brain barrier (BBB), the …

Ginkgo biloba and long COVID: in vivo and in vitro models for the evaluation of nanotherapeutic efficacy

T Akanchise, A Angelova - Pharmaceutics, 2023 - mdpi.com
Coronavirus infections are neuroinvasive and can provoke injury to the central nervous
system (CNS) and long-term illness consequences. They may be associated with …

Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and …

G Magni, B Riboldi, K Petroni, S Ceruti - Biochemical Pharmacology, 2022 - Elsevier
In recent years, experimental evidence suggested a possible role of the gut microbiota in the
onset and development of several neurodegenerative disorders, such as AD and PD, MS …

[HTML][HTML] p-Coumaric acid mitigates passive avoidance memory and hippocampal synaptic plasticity impairments in aluminum chloride-induced Alzheimer's disease rat …

M Rashno, P Gholipour, I Salehi, A Komaki… - Journal of Functional …, 2022 - Elsevier
The present study was designed to determine the effects of p-coumaric acid (p-CA), a
phenolic compound, on passive avoidance memory function and hippocampal long-term …

[HTML][HTML] Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis

AA Sallam, MA El-Magd, MM Ahmed, HI Ghamry… - Biomedicine & …, 2022 - Elsevier
Recently, we reported that quercetin (Que) could alleviate immunotoxicity induced by
pristine multi-walled carbon nanotubes (MWCNTs) in mice. In the present study, we …

Potential role of nanoparticles in treating the accumulation of amyloid-beta peptide in Alzheimer's patients

M Abbas - Polymers, 2021 - mdpi.com
The disorder of Alzheimer's is marked by progressive pathophysiological
neurodegeneration. The amino acid peptides in the amyloid plaques found in the brains of …