Renal cell carcinomas (RCCs) are a diverse set of malignancies that have recently been
shown to harbour mutations in a number of chromatin modifier genes—including PBRM1 …

The spatio-temporal regulation of gene expression determines the fate and function of
various cells and tissues and, as a consequence, the correct development and functioning of …

How mis-regulated chromatin directly impacts human immune disorders is poorly
understood. Speckled Protein 140 (SP140) is an immune-restricted PHD and bromodomain …

Insect pests negatively affect crop quality and yield; identifying new methods to protect crops
against insects therefore has important agricultural applications. Our analysis of transgenic …

The nervous and immune systems are closely entwined to maintain the immune balance in
health and disease. Here, we showed that LPS can activate suprarenal and celiac ganglia …

Mitogen‐activated protein kinase (MAPK) signaling plays a significant role in reactive
oxygen species (ROS) production. The authors have previously shown that Brahma‐related …

Highlights•Epigenetics is a therapeutically tractable mechanism linking genetics and
environmental cues in IBD.•Variants of human epigenetic regulators or regulatory regions …

The humoral arm of host defense in Drosophila relies on two evolutionarily conserved NFκB
signaling cascades, the Toll and the immune deficiency (Imd) pathways. The Imd signaling …

Metazoans have developed strategies to protect themselves from pathogenic attack. These
preserved mechanisms constitute the immune system, composed of innate and adaptive …

Inflammatory bowel disease (IBD) is a chronic, systemic gastrointestinal disorder
characterized by episodic inflammation that requires life-long management. Although the …