The ability of mammals to mount adaptive immune responses culminating with the
establishment of immunological memory is predicated on the ability of the mature T cell …

Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in
shaping adaptive immunity. DCs have a unique ability to sample their environment, capture …

Harnessing the patient's immune system to control a tumor is a proven avenue for cancer
therapy. T cell therapies as well as therapeutic vaccines, which target specific antigens of …

Background Human papillomavirus (HPV)-negative head and neck squamous cell
carcinoma (HNSCC) remains a treatment-resistance disease with limited response to …

Two hypermutated colon cancer cases with patient-derived cell lines, peripheral and tumor-
infiltrating T cells available were selected for detailed investigation of immunological …

Peptides presented by MHC proteins regulate all aspects of T cell biology. These MHC-
associated peptides (MAPs) form what is known as the immunopeptidome and their …

Although significant advances in immunotherapy have revolutionized the treatment of many
cancer types over the past decade, the field of vaccine therapy, an important component of …

Cancer immunotherapy has become an indispensable mode of treatment for a multitude of
solid tumor cancers. Colorectal cancer (CRC) has been one of the many cancer types to …

Adoptive cell therapy (ACT) using specific immune cells and stem cells has emerged as a
promising treatment option that could complement traditional cancer therapies in the future …

Adoptive immunotherapy in the T cell landscape exhibits efficacy in cancer treatment. Over
the past few decades, genetically modified T cells, particularly chimeric antigen receptor T …