Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial intelligence

SZ Alshawwa, AA Kassem, RM Farid, SK Mostafa… - Pharmaceutics, 2022 - mdpi.com
There has been an increasing demand for the development of nanocarriers targeting
multiple diseases with a broad range of properties. Due to their tiny size, giant surface area …

PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application

P Grossen, D Witzigmann, S Sieber… - Journal of Controlled …, 2017 - Elsevier
The lack of efficient therapeutic options for many severe disorders including cancer spurs
demand for improved drug delivery technologies. Nanoscale drug delivery systems based …

[HTML][HTML] Polymeric lipid hybrid nanoparticles (plns) as emerging drug delivery platform—A comprehensive review of their properties, preparation methods, and …

D Sivadasan, MH Sultan, O Madkhali, Y Almoshari… - Pharmaceutics, 2021 - mdpi.com
Polymeric lipid hybrid nanoparticles (PLNs) are core–shell nanoparticles made up of a
polymeric kernel and lipid/lipid–PEG shells that have the physical stability and …

The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade

A Wiehe, MO Senge - Photochemistry and Photobiology, 2023 - Wiley Online Library
This review follows the research, development and clinical applications of the
photosensitizer 5, 10, 15, 20‐tetra (m‐hydroxyphenyl) chlorin (m THPC, temoporfin) in …

[HTML][HTML] Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry

L Peltonen - Advanced drug delivery reviews, 2018 - Elsevier
The number of poorly soluble drug candidates is increasing, and this is also seen in the
research interest towards drug nanoparticles and (nano-) cocrystals; improved solubility is …

Nanomedicines-tiny particles and big challenges

MRC Marques, Q Choo, M Ashtikar, TC Rocha… - Advanced Drug Delivery …, 2019 - Elsevier
After decades of research, nanotechnology has been used in a broad array of biomedical
products including medical devices, drug products, drug substances, and pharmaceutical …

Nanopharmaceuticals for wound healing–lost in translation?

M Ashtikar, MG Wacker - Advanced drug delivery reviews, 2018 - Elsevier
Today, many of the newly developed pharmaceuticals and medical devices take advantage
of nanotechnology and with a rising incidence of chronic diseases such as diabetes and …

How to measure release from nanosized carriers?

L Nothnagel, MG Wacker - European Journal of Pharmaceutical Sciences, 2018 - Elsevier
Novel drug delivery systems exhibit great potential in the formulation of poorly soluble
compounds but have also been applied to reduce side effects of highly active drug …

Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection

GF Gao, M Ashtikar, R Kojima, T Yoshida… - Journal of controlled …, 2021 - Elsevier
Today, tacrolimus represents a cornerstone of immunosuppressive therapy for liver and
kidney transplants and remains subject of preclinical and clinical investigations, aiming at …

Comparison of thermosensitive in situ gels and drug-resin complex for ocular drug delivery: In vitro drug release and in vivo tissue distribution

Y Wei, C Li, Q Zhu, X Zhang, J Guan, S Mao - International Journal of …, 2020 - Elsevier
Conventional ophthalmic eye drops are limited by their rapid elimination rate and short time
of action. Ion exchange resin has been used to achieve sustained ocular drug delivery but …