The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …

Fibrosis plays an important role in many different pathologies. It results from tissue injury,
chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized …

Purpose The lack of effective molecular biomarkers to monitor idiopathic pulmonary fibrosis
(IPF) activity or treatment response remains an unmet clinical need. Herein, we determined …

Background Dynamic contrast-enhanced (DCE) photoacoustic (PA) imaging (PAI) is a novel
noninvasive imaging modality that uses the differences in optical absorption of …

Fibrosis, the progressive accumulation of connective tissue that occurs in response to injury,
causes irreparable organ damage and may result in organ failure. The few available …

During fibroproliferation, protein-associated extracellular aldehydes are formed by the
oxidation of lysine residues on extracellular matrix proteins to form the aldehyde allysine …

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with short
survival time. However, owing to the unknown etiology and the lack of sensitive and …

Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a
common result of chronic tissue injury. Advances in the clinical management of fibrotic …

Pulmonary fibrosis (PF) is the pathologic accumulation of extracellular matrix components in
lung tissue that result in scarring following chronic lung injury. PF is typically diagnosed by …

Cardiovascular imaging is evolving in response to systemwide trends toward molecular
characterization and personalized therapies. The development of new radiotracers for PET …