Genome structural variation in human evolution

EJ Hollox, LW Zuccherato, S Tucci - Trends in Genetics, 2022 - cell.com
Structural variation (SV) is a large difference (typically> 100 bp) in the genomic structure of
two genomes and includes both copy number variation and variation that does not change …

From telomere to telomere: The transcriptional and epigenetic state of human repeat elements

SJ Hoyt, JM Storer, GA Hartley, PGS Grady… - Science, 2022 - science.org
Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …

The evolution and changing ecology of the African hominid oral microbiome

JA Fellows Yates, IM Velsko, F Aron… - Proceedings of the …, 2021 - National Acad Sciences
The oral microbiome plays key roles in human biology, health, and disease, but little is
known about the global diversity, variation, or evolution of this microbial community. To …

How natural genetic variation shapes behavior

N Niepoth, A Bendesky - Annual review of genomics and human …, 2020 - annualreviews.org
Nervous systems allow animals to acutely respond and behaviorally adapt to changes and
recurring patterns in their environment at multiple timescales—from milliseconds to years …

Micro and macroevolution of sea anemone venom phenotype

EG Smith, JM Surm, J Macrander, A Simhi… - Nature …, 2023 - nature.com
Venom is a complex trait with substantial inter-and intraspecific variability resulting from
strong selective pressures acting on the expression of many toxic proteins. However …

Macronutrients and human health for the 21st century

BJ Venn - Nutrients, 2020 - mdpi.com
Fat, protein and carbohydrate are essential macronutrients. Various organisations have
made recommendations as to the energy contribution that each of these components makes …

Recurrent evolution and selection shape structural diversity at the amylase locus

D Bolognini, A Halgren, RN Lou, A Raveane, JL Rocha… - Nature, 2024 - nature.com
The adoption of agriculture triggered a rapid shift towards starch-rich diets in human
populations. Amylase genes facilitate starch digestion, and increased amylase copy number …

[HTML][HTML] Functional specialization of human salivary glands and origins of proteins intrinsic to human saliva

M Saitou, EA Gaylord, E Xu, AJ May, L Neznanova… - Cell reports, 2020 - cell.com
Salivary proteins are essential for maintaining health in the oral cavity and proximal
digestive tract, and they serve as potential diagnostic markers for monitoring human health …

Parallel nonfunctionalization of CK1δ/ε kinase ohnologs following a whole-genome duplication event

D Evans-Yamamoto, AK Dubé, G Saha… - Molecular Biology …, 2023 - academic.oup.com
Whole-genome duplication (WGD) followed by speciation allows us to examine the parallel
evolution of ohnolog pairs. In the yeast family Saccharomycetaceae, HRR25 is a rare case …

Molecular adaptation and convergent evolution of frugivory in Old World and neotropical fruit bats

K Wang, S Tian, J Galindo‐González… - Molecular …, 2020 - Wiley Online Library
Although cases of independent adaptation to the same dietary niche have been
documented in mammalian ecology, the molecular correlates of such shifts are seldom …