Lactic acid production has been regarded as a mechanism by which malignant cells escape
immunosurveillance. Recent technological advances in mass spectrometry and the use of …

Malignant melanoma is notorious for its inter-and intratumour heterogeneity, based on
transcriptionally distinct melanoma cell phenotypes. It is thought that these distinct …

The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …

Intratumoral stimulatory dendritic cells (SDCs) play an important role in stimulating cytotoxic
T cells and driving immune responses against cancer. Understanding the mechanisms that …

Malignant transformation can result in melanoma cells that resemble different stages of their
embryonic development. Our gene expression analysis of human melanoma cell lines and …

Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …

Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can
provide important prognostic information in diverse solid tumor types, and may also be of …

Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant
BRAF or fail to respond to checkpoint blockade. We explored whether modulation of …

We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

Intratumoral dendritic cells (DC) bearing CD103 in mice or CD141 in humans drive
intratumoral CD8+ T cell activation. Using multiple strategies, we identified a critical role for …