Introduction Variants in the tau gene (MAPT) region are associated with breast cancer in
women and Alzheimer's disease (AD) among persons lacking apolipoprotein E ε4 (ε4–) …

The silencing of the tumor suppressor gene O-6-methylguanine-DNA methyltransferase
(MGMT) by promoter methylation commonly occurs in human cancers. The relationship …

Background DNA hypermethylation is a key epigenetic mechanism for the silencing of many
genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce …

Gallbladder cancer (GBC) is an aggressive malignancy with a poor prognosis, often
diagnosed at advanced stages due to subtle early symptoms. Recent studies have provided …

Aberrant patterns in promoter methylation of tumor‐suppressor genes and posttranslational
modifications of histone proteins are considered as major features of malignancy. In this …

MicroRNAs (miRNAs) are a large family of small, approximately 20–22 nucleotide,
noncoding RNAs that regulate the expression of target genes, at the post-transcriptional …

Abstract Background/Aims: Numerous studies have suggested that the promoter methylation
status of O6-methylguanine-DNA methyltransferase (MGMT) is significantly associated with …

The clinical relevance of aberrant DNA methylation is being increasingly recognized in
breast cancer. The present study aimed to evaluate the promoter methylation status of seven …

Triple-negative breast cancer (TNBC) is typically treated with chemotherapeutic agents,
including carboplatin (Cb), an DNA platinating agent. The O6-methylguanine-DNA …

The involvement of alterations in MLH1, an essential mismatch repair component, in BRAF
V600E mutated papillary thyroid carcinoma (PTC) has been suggested to be associated with …