[HTML][HTML] Osteopontin in bone metabolism and bone diseases

J Si, C Wang, D Zhang, B Wang, W Hou… - … medical journal of …, 2020 - ncbi.nlm.nih.gov
Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding
ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many …

[HTML][HTML] Osteopontin as a multifaceted driver of bone metastasis and drug resistance

X Pang, K Gong, X Zhang, S Wu, Y Cui… - Pharmacological research, 2019 - Elsevier
Metastasis to bone frequently occurs in majority of patients with advanced breast cancer and
prostate cancer, leading to devastating skeletal-related events and substantially reducing …

Injectable chitosan/β-glycerophosphate hydrogels with sustained release of BMP-7 and ornidazole in periodontal wound healing of class III furcation defects

S Zang, R Mu, F Chen, X Wei, L Zhu, B Han… - Materials Science and …, 2019 - Elsevier
The aim of this study was to determine the effect of bone morphogenetic protein-7 (BMP-7)
and ornidazole (ORN) loaded Chitosan/β-glycerophosphate (CS/β-GP) thermosensitive …

Current limitations and candidate potential of 5-HT7 receptor antagonism in psychiatric pharmacotherapy

R Okubo, T Hasegawa, K Fukuyama… - Frontiers in …, 2021 - frontiersin.org
Several mood-stabilizing atypical antipsychotics and antidepressants weakly block
serotonin (5-HT) receptor type-7 (5-HT7R); however, the contributions of 5-HT7R …

Osteoclasts secrete osteopontin into resorption lacunae during bone resorption

J Luukkonen, M Hilli, M Nakamura, I Ritamo… - Histochemistry and cell …, 2019 - Springer
Osteopontin (OPN) is a non-collagenous extracellular sialylated glycoprotein located in
bone. It is believed to be one of the key components in osteoclast attachment to bone during …

Role of nitric oxide in orthodontic tooth movement

T Yan, Y Xie, H He, W Fan… - … journal of molecular …, 2021 - spandidos-publications.com
Nitric oxide (NO) is an ubiquitous signaling molecule that mediates numerous cellular
processes associated with cardiovascular, nervous and immune systems. NO also plays an …

[HTML][HTML] Overcoming irinotecan resistance by targeting its downstream signaling pathways in colon cancer

S Saurav, S Karfa, T Vu, Z Liu, A Datta, U Manne… - Cancers, 2024 - mdpi.com
Simple Summary Treatments for colorectal cancer (CRC) largely rely on chemotherapeutics.
For CRC treatment, irinotecan is widely used in various combinations with other drugs …

The role of Meteorin‐like in skeletal development and bone fracture healing

R Huang, AR Balu, KH Molitoris… - Journal of …, 2022 - Wiley Online Library
Abstract Meteorin‐like protein (Metrnl), homologous to the initially identified neurotrophic
factor Meteorin, is a secreted, multifunctional protein. Here we used mouse models to …

Biomaterial and implant induced ossification: in vitro and in vivo findings

PK Vallittu, JP Posti, JM Piitulainen… - Journal of tissue …, 2020 - Wiley Online Library
Material‐induced ossification is suggested as a suitable approach to heal large bone
defects. Fiber‐reinforced composite–bioactive glasses (FRC‐BGs) display properties that …

Influence of the components and orientation of hydroxyapatite fibrous substrates on osteoblast behavior

SW Tsai, YW Hsu, WL Pan, A Vadivelmurugan… - Journal of Functional …, 2022 - mdpi.com
Synthetic hydroxyapatite has good biocompatibility, bioactivity and osteoconductive ability
because its chemical properties and biological properties are similar to those of bioapatite in …