Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …

MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately
and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the …

Magnetic resonance-guided focused ultrasound in combination with intravenously injected
microbubbles has been shown to transiently open the blood–brain barrier, and reduce beta …

Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Chimeric antigen receptor T-cell (CAR-T) therapy is the result of combining genetic
engineering-based cancer immunotherapy with adoptive cell therapy (ACT). CAR-T therapy …

The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which is mainly
characterized by progressive impairment in cognition, emotion, language and memory in …