Mutations in BRCA1 and BARD1 predispose carriers to breast and ovarian cancers. The
BRCA1 and BARD1 proteins form a heterodimeric complex (BRCA1/BARD1) that regulates …

Mutations in the E3 ubiquitin ligase RING domains of BRCA1/BARD1 predispose carriers to
breast and ovarian cancers. We present the structure of the BRCA1/BARD1 RING …

The incorporation of histone variants has structural ramifications on nucleosome dynamics
and stability. Due to their unique sequences, histone variants can alter histone–histone or …

Abstract The H2A. B histone variant is an epigenetic regulator involved in transcriptional
upregulation, DNA synthesis, and splicing that functions by replacing the canonical H2A …

Small extracellular vesicles (sEVs) are cell‐derived vesicles evolving as important elements
involved in all stages of cancers. sEVs bear unique protein signatures that may serve as …

Simple Summary NRAS mutations constitutively activate cell proliferation signaling in
malignant tumors. The elucidation of NRAS downstream signaling genes may lead to the …

Breast cancer type-1 susceptibility protein (BRCA1) was the first gene to be linked to
heritable breast and ovarian cancer over thirty years ago. Since then, remarkable progress …

Cancer develops due to the accumulation of genetic and epigenetic changes caused by
various factors. An important source of genetic changes is DNA double-strand breaks …

Metastasis describes the spread of cancer cells from the site of the primary tumor through
the basement membrane, into the circulation, and to a distant site. In order to accomplish …

Ovarialtumoren gehören zu den fünf häufigsten Tumoren der Frau in der westlichen Welt [1].
Mit 3, 2% aller bösartigen Neubildungen der Frauen und 5, 3% aller Krebssterbefälle ist der …