Unleashing the Synthetic Power of Plant Oxygenases: From Mechanism to Application | Plant
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Methylation of cytosine bases is strongly linked to gene expression, imprinting, aging, and
carcinogenesis. The ten-eleven translocation (TET) family of enzymes, which are Fe (II)/2 …

The study of epigenetics has greatly benefited from the development and application of
various chemical biology approaches. In this review, we highlight the key targets for …

Oxoglutarate (2OG) oxygenases are validated agrochemical and human drug targets. The
potential for modulating their activity with 2OG derivatives has not been explored, possibly …

Enzymes of the ten-eleven translocation (TET) family add diversity to the repertoire of
nucleobase modifications by catalyzing the oxidation of 5-methylcytosine (5mC). TET …

Abstract The Cu‐catalyzed Ullmann‐Goldberg cross‐coupling between aryl iodides and
oxamates is shown to afford the corresponding N‐aryloxamates with yields ranging from …

Conditional remodeling of enzyme catalysis is a formidable challenge in protein
engineering. Herein, we have undertaken a unique active site engineering tactic to …

Abstract α-ketoglutarate (αKG) is a central metabolic node with a broad influence on cellular
physiology. The αKG analogue N-oxalylglycine (NOG) and its membrane-permeable pro …

Ten-eleven-translocation (TET) dioxygenases catalyze the oxidation of 5-methylcytosine
(5mC), the central epigenetic regulator of mammalian DNA. This activity dynamically …

2-Oxoglutarate (2OG) is involved in biological processes including oxidations catalyzed by
2OG oxygenases for which it is a cosubstrate. Eukaryotic 2OG oxygenases have roles in …