Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics

J Saarbach, PM Sabale, N Winssinger - Current opinion in chemical …, 2019 - Elsevier
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …

[HTML][HTML] Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

N Brodyagin, M Katkevics, V Kotikam… - Beilstein journal of …, 2021 - beilstein-journals.org
Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications

C Suparpprom, T Vilaivan - RSC Chemical Biology, 2022 - pubs.rsc.org
Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …

A minimal hybridization chain reaction (HCR) system using peptide nucleic acids

KT Kim, S Angerani, N Winssinger - Chemical Science, 2021 - pubs.rsc.org
The HCR represents a powerful tool for amplification in DNA-based circuitry and sensing
applications, yet requires the use of long DNA sequences to grant hairpin metastability. Here …

Evolution of peptide nucleic acid with modifications of its backbone and application in biotechnology

A Das, B Pradhan - Chemical Biology & Drug Design, 2021 - Wiley Online Library
Peptide nucleic acids (PNAs) are getting prodigious interest currently in the biomedical and
diagnostic field as an extremely powerful tool because of their potentiality to hybridize with …

Supernatural: Artificial Nucleobases and Backbones to Program Hybridization-Based Assemblies and Circuits

M Lopez-Tena, SK Chen, N Winssinger - Bioconjugate Chemistry, 2022 - ACS Publications
The specificity and predictability of hybridization make oligonucleotides a powerful platform
to program assemblies and networks with logic-gated responses, an area of research which …

Peptide nucleic acids and their role in gene regulation and editing

JDR Perera, KEW Carufe, PM Glazer - Biopolymers, 2021 - Wiley Online Library
The unique properties of peptide nucleic acid (PNA) makes it a desirable candidate to be
used in therapeutic and biotechnological interventions. It has been broadly utilized for …

Modulation of DNA and RNA by PNA

P Muangkaew, T Vilaivan - Bioorganic & Medicinal Chemistry Letters, 2020 - Elsevier
Peptide nucleic acid (PNA), a synthetic DNA mimic that is devoid of the (deoxy) ribose-
phosphate backbone yet still perfectly retains the ability to recognize natural nucleic acids in …

Cγ(S/R)-Bimodal Peptide Nucleic Acids (Cγ-bm-PNA) Form Coupled Double Duplexes by Synchronous Binding to Two Complementary DNA Strands

P Bhingardeve, BR Madhanagopal… - The Journal of Organic …, 2020 - ACS Publications
Peptide nucleic acids (PNAs) are linear equivalents of DNA with a neutral acyclic polyamide
backbone that has nucleobases attached via tert-amide link on repeating units of …

Structural design and synthesis of bimodal PNA that simultaneously binds two complementary DNAs to form fused double duplexes

MK Gupta, BR Madhanagopal, D Datta… - Organic …, 2020 - ACS Publications
Bimodal PNAs are new PNA constructs designed to bind two different cDNA sequences
synchronously to form double duplexes. They are synthesized on solid phase using …