As synthetic biology approaches are extended to diverse applications throughout medicine,
biotechnology and basic biological research, there is an increasing need to engineer yeast …

Neuronal histone acetylation has been postulated to be a mnemonic substrate and a target
for memory enhancers and neuropsychiatric drugs. Here we critically evaluate this view and …

ADP-ribosylation of nuclear proteins is a critical feature of various DNA damage repair
pathways. Histones, particularly H3 and H2B, are major targets of ADP-ribosylation and are …

Cellular identity in multicellular organisms is maintained by characteristic transcriptional
networks, nutrient consumption, energy production and metabolite utilization. Integrating …

The development of high‐speed analytical techniques such as next‐generation sequencing
and microarrays allows high‐throughput analysis of biological information at a low cost …

Highlights•Histones with specific PTMs can be synthesised and assembled in designer
nucleosomes.•Codon suppression, semisynthesis or chemical mutagenesis allows …

We introduce a hybrid solid-solution phase ligation approach that combines the efficiency of
solid phase ligation with solution phase ligation in the total synthesis of modified histone …

Background Mind-body therapies (MBTs) are used throughout the world in treatment,
disease prevention, and health promotion. However, the mechanisms by which MBTs exert …

The genomic DNA of eukaryotic cells exists in the form of chromatin, the structure of which
controls the biochemical accessibility of the underlying DNA to effector proteins. In order to …

Chromatin is a system of proteins, RNA, and DNA that interact with each other to organize
and regulate genetic information within eukaryotic nuclei. Chromatin proteins carry out …