Viral diseases like influenza, AIDS, hepatitis, and Ebola cause severe epidemics worldwide.
Along with their resistant strains, new pathogenic viruses continue to be discovered so …

Abnormal gene expression level or expression of genes containing deleterious mutations
are two of the main determinants which lead to genetic disease. To obtain a therapeutic …

Background Epigenome editing refers to the targeted reprogramming of genomic loci using
an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the …

Objective Observational studies have posited a strong correlation between chronic gastritis
(CG) and major depressive disorder (MDD), but the nature of this association remains …

Pulmonary fibrosis (PF) is the end stage of severe lung diseases, in which the lung
parenchyma is replaced by fibrous scar tissue. The result is a remarkable reduction in …

The CRISPR-based genome editing holds immense potential to fix disease-causing
mutations, however, must also handle substantial natural genetic variations between …

Domestic dogs are important for many economic and social reasons, and they have become
a well-known model species for human disease. According to research, dog breeds exhibit …

Rationale: PIWI-interacting RNAs (piRNAs) are a recently-discovered class of small
noncoding RNAs (ncRNAs) with a length of 21-35 nucleotides. They play a role in gene …

Allele-specific genomic targeting by CRISPR is a versatile strategy that has been
increasingly exploited not only in treating inherited dominant diseases and mutation-driven …

Cancers are diseases caused by genetic and non-genetic environmental factors. Epigenetic
alterations, some attributed to non-genetic factors, can lead to cancer development …