[18 F] fluoro-2-deoxy-d-glucose (FDG) is currently the only fluorinated tracer used in routine
clinical positron emission tomography (PET). Fluorine-18 is considered the ideal …

Tumor receptors play an important role in carcinogenesis and tumor growth and have been
some of the earliest targets for tumor-specific therapy, for example, the estrogen receptor in …

Abstract Introduction 16α-[18 F] Fluoroestradiol (FES), a PET radiotracer for the estrogen
receptor (ER) in breast cancer, was the first receptor-targeted PET radiotracer for oncology …

Over the past decade, the role of radiology in breast cancer has changed significantly
because of the technical advances in mammography, greater use of ultrasonography, and …

Breast cancer is one of the most common malignancies in women, with high morbidity and
mortality rates. In breast cancer, the use of novel radiopharmaceuticals in nuclear medicine …

Sex steroid hormones are major regulators of sexual characteristic among species. These
hormones, however, are also produced in the brain. Steroidal hormone‐mediated signalling …

Abstract Treatment decisions in oncology are increasingly guided by information on the
biologic characteristics of tumors. Currently, patient-specific information on tumor biology is …

Molecular imaging plays an increasingly important role in the diagnosis and treatment of
different malignancies. Radiolabeled probes enable the visualization of the primary tumor as …

Steroid receptors regulate gene expression for many important physiologic functions and
pathologic processes. Receptors for estrogen, progesterone, and androgen have been …

Many breast and prostate cancers are driven by the action of steroid hormones on their
cognate receptors in primary tumors and in metastases, and endocrine therapies that inhibit …