The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea

A Altoè, CA Shera - Journal of the Association for Research in …, 2023 - Springer
The cochlea of the mammalian inner ear includes an active, hydromechanical amplifier
thought to arise via the piezoelectric action of the outer hair cells (OHCs). A classic problem …

Megahertz sampling of prestin (SLC26a5) voltage-sensor charge movements in outer hair cell membranes reveals ultrasonic activity that may support electromotility …

J Santos-Sacchi, JP Bai… - Journal of Neuroscience, 2023 - Soc Neuroscience
Charged moieties in the outer hair cell (OHC) membrane motor protein, prestin, are driven
by transmembrane voltage to power OHC electromotility (eM) and cochlear amplification …

Optogenetics reveals roles for supporting cells in force transmission to and from outer hair cells in the mouse cochlea

VA Lukashkina, S Levic, P Simões, Z Xu… - Journal of …, 2024 - Soc Neuroscience
Outer hair cells (OHCs) of the organ of Corti (OoC), acting as bidirectional cellular
mechanoelectrical transducers, generate, receive, and exchange forces with other major …

Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea

WC Lin, A Macić, J Becker, JH Nam - Communications Biology, 2024 - nature.com
Pending questions regarding cochlear amplification and tuning are hinged upon the organ
of Corti (OoC) active mechanics: how outer hair cells modulate OoC vibrations. Our …

Fluctuating flexoelectric membranes in asymmetric viscoelastic media: Power spectrum through mechanical network and transfer function models

EE Herrera-Valencia, AD Rey - Symmetry, 2023 - mdpi.com
Flexoelectric liquid crystalline membranes immersed in asymmetric viscoelastic media is a
material system model with physiological applications such as outer hair cells (OHCs) …

Local cochlear mechanical responses revealed through outer hair cell receptor potential measurements

AN Lukashkin, IJ Russell, O Rybdylova - Biophysical Journal, 2024 - cell.com
Sensory hair cells, including the sensorimotor outer hair cells, which enable the sensitive,
sharply tuned responses of the mammalian cochlea, are excited by radial shear between the …

Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation

W Cai, K Grosh - Biophysical Journal, 2024 - cell.com
The outer hair cells (OHCs) of the mammalian cochlea are the mediators of an active,
nonlinear electromechanical process necessary for sensitive, frequency-specific hearing …

Outer hair cell receptor potentials reveal a local resonance in the mammalian cochlea

AN Lukashkin, IJ Russell, O Rybdylova - bioRxiv, 2023 - biorxiv.org
Sensory hair cells, including the sensorimotor outer hair cells, which enable the sensitive,
sharply tuned responses of the mammalian cochlea, are excited by radial shear between the …