Mutations in the skeletal muscle alpha-actin gene (ACTA1) associated with congenital
myopathy with excess of thin myofilaments, nemaline myopathy and intranuclear rod …

This is the first of a projected series of canonic reviews covering all invertebrate muscle
literature prior to 2005 and covers muscle genes and proteins except those involved in …

Glia are the most abundant cell type in the mammalian brain. They regulate neuronal
development and function, CNS immune surveillance, and stem cell biology, yet we know …

The distal arthrogryposes (DAs) are a group of disorders characterized by multiple
congenital contractures of the limbs. We previously mapped a locus for DA type 2B (DA2B) …

A synthetic gene drive that targets haplolethal genes on the X chromosome can skew the
sex ratio toward males. Like an “X-shredder,” it does not involve “homing,” and that has …

Advances in molecular genetics have led to the identification of mutations in each troponin
subunit that cause different human cardiomyopathies. Mutations in the genes for cardiac …

This essay reviews the long tradition of experimental genetics of the Drosophila indirect
flight muscles (IFM). It discusses how genetics can operate in tandem with multidisciplinary …

In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight
and leg muscles are the major voluntary locomotory organs. They share several …

Mutations in the cardiac troponin I (CTnI) gene occur in∼ 5% of families with familial
hypertrophic cardiomyopathy (FHC) and 20 mutations in this gene that cause FHC have now …

The indirect flight muscles (IFM) of Drosophila melanogaster provide a good genetic system
with which to investigate muscle function. Flight muscle contraction is regulated by both …