[HTML][HTML] HAX1: A versatile, intrinsically disordered regulatory protein

A Trębińska-Stryjewska, M Wakula… - … et Biophysica Acta (BBA …, 2023 - Elsevier
HAX1 is a relatively small, ubiquitously expressed, predominantly mitochondrial, intrinsically
disordered protein. It has been implicated in the regulation of apoptosis, cell migration …

NOD1 cooperates with HAX‐1 to promote cell migration in a RIPK2‐and NF‐ĸB‐independent manner

L Hezinger, S Bauer, K Ellwanger… - The FEBS …, 2023 - Wiley Online Library
The human Nod‐like receptor protein NOD1 is a well‐described pattern‐recognition
receptor (PRR) with diverse functions. NOD1 associates with F‐actin and its protein levels …

HAX1 enhances the survival and metastasis of non‐small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway

Z Liang, Y Zhong, L Meng, Y Chen, Y Liu, A Wu… - Thoracic …, 2020 - Wiley Online Library
Background HS‐1‐associated protein‐1 (HAX1) has been reported to be overexpressed in
non‐small cell lung cancer (NSCLC) tissues. However, the underlying mechanism of HAX1 …

Viral determinants influencing intra-and intercellular communication in cytomegalovirus infection

K Szymanska-de Wijs, M Dezeljin, B Bogdanow… - Current Opinion in …, 2023 - Elsevier
Cytomegaloviruses (CMVs) are typically disseminated by cell-to-cell transfer, which requires
reprogramming of cellular signaling pathways and restructuring of the cell architecture. Viral …

MicroRNA‑125a‑5p regulates liver cancer cell growth, migration and invasion and EMT by targeting HAX1

Z Zha, J Li - International Journal of Molecular Medicine, 2020 - spandidos-publications.com
To date, the role of hematopoietic‑substrate‑1‑associated protein X‑1 (HAX1) in liver cancer
is rarely studied. The present study explored the role of HAX1 in liver cancer. The …

Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia

U Mahat, B Garg, CY Yang, H Mehta, R Hanna… - Blood …, 2022 - ashpublications.org
Neutrophils migrate into inflamed tissue, engage in phagocytosis, and clear pathogens or
apoptotic cells. These processes require well-coordinated events involving the actin …

The interactome of multifunctional HAX1 protein suggests its role in the regulation of energy metabolism, de-aggregation, cytoskeleton organization and RNA …

M Wakula, A Balcerak, T Rubel… - Bioscience …, 2020 - portlandpress.com
Abstract HCLS1-associated protein X-1 (HAX1) is a multifunctional protein involved in many
cellular processes, including apoptosis, cell migration and calcium homeostasis, but its …

Targeting c-Jun is a potential therapy for luminal breast cancer bone metastasis

Y Han, S Katayama, M Futakuchi, K Nakamichi… - Molecular Cancer …, 2023 - AACR
Luminal breast cancer has the highest bone metastasis frequency among all breast cancer
subtypes; however, its metastatic mechanism has not been elucidated because of a lack of …

A Multi-Faceted Analysis Showing CRNDE Transcripts and a Recently Confirmed Micropeptide as Important Players in Ovarian Carcinogenesis

A Balcerak, LA Szafron, T Rubel, B Swiderska… - International Journal of …, 2024 - mdpi.com
CRNDE is considered an oncogene expressed as long non-coding RNA. Our previous
paper is the only one reporting CRNDE as a micropeptide-coding gene. The amino acid …

Expression of Integrin β6 and HAX-1 correlates with aggressive features and poor prognosis in esophageal squamous cell carcinoma

F Li, Y Shang, F Shi, L Zhang, J Yan… - Cancer Management …, 2020 - Taylor & Francis
Purpose The development of esophageal squamous cell carcinoma (ESCC) is a
complicated process in which cell adhesion and motility, mediated by integrins, are involved …