Experimental animal models for COPD: a methodological review

V Ghorani, MH Boskabady, MR Khazdair… - Tobacco induced …, 2017 - Springer
Introduction Chronic obstructive pulmonary disease (COPD) is a progressive disorder that
makes the breathing difficult and is characterized by pathological conditions ranging from …

Smoking and inflammation: evidence for a synergistic role in chronic disease

A Johannsen, C Susin, A Gustafsson - Periodontology 2000, 2014 - Wiley Online Library
Tobacco smoking is the most important preventable risk factor for periodontitis; however, the
underlying biological mechanisms responsible for the detrimental effects of smoking on …

Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome

ES Wan, W Qiu, A Baccarelli, VJ Carey… - Human molecular …, 2012 - academic.oup.com
The impact of cigarette smoking can persist for extended periods following smoking
cessation and may involve epigenetic reprogramming. Changes in DNA methylation …

Animal models of COPD: W hat do they tell us?

B Jones, C Donovan, G Liu, HM Gomez… - …, 2017 - Wiley Online Library
ABSTRACT COPD is a major cause of global mortality and morbidity but current treatments
are poorly effective. This is because the underlying mechanisms that drive the development …

Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox

MS Eapen, S Myers, EH Walters… - Expert review of …, 2017 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) is primarily an airway
condition, which mainly affects cigarette smokers and presents with shortness of breath that …

Animal models of chronic obstructive pulmonary disease

M Fricker, A Deane, PM Hansbro - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of
mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for …

Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans

YV Sun, AK Smith, KN Conneely, Q Chang, W Li… - Human genetics, 2013 - Springer
Cigarette smoking is an environmental risk factor for many chronic diseases, and disease
risk can often be managed by smoking control. Smoking can induce cellular and molecular …

Tobacco smoke induced COPD/emphysema in the animal model—are we all on the same page?

M Leberl, A Kratzer, L Taraseviciene-Stewart - Frontiers in physiology, 2013 - frontiersin.org
Chronic Obstructive Pulmonary Disease (COPD) is one of the foremost causes of death
worldwide. It is primarily caused by tobacco smoke, making it an easily preventable disease …

[HTML][HTML] A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or …

B Phillips, E Veljkovic, MJ Peck, A Buettner… - Food and Chemical …, 2015 - Elsevier
Modified risk tobacco products (MRTP) are designed to reduce smoking-related health risks.
A murine model of chronic obstructive pulmonary disease (COPD) was applied to …

Electronic cigarette exposure disrupts blood-brain barrier integrity and promotes neuroinflammation

NA Heldt, A Seliga, M Winfield, S Gajghate… - Brain, behavior, and …, 2020 - Elsevier
Electronic cigarette (e-cigarette) use has grown substantially since inception, particularly
among adolescents and combustible tobacco users. Several cigarette smoke constituents …