Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …

Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

Neuroinflammation in the brain contributes to the pathogenesis of Parkinson's disease (PD),
but the potential dysregulation of peripheral immunity has not been systematically …

Abstract Purpose of Review Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are auto-
inflammatory and autoimmune diseases with a highly selective tissue tropism for medium …

The T cell compartment undergoes characteristic changes with age, which contribute to
increased incidence and severity of infections and reduced immunogenicity and efficacy of …

Alterations in the immune system with aging are considered to underlie many age-related
diseases. However, many elderly individuals remain healthy until even a very advanced …

Introduction Aging causes several changes in the immune system, although immune aging
is strongly influenced by individual immunological history, as well as genetic and …

The immunophenotype of oldest centenarians, ie semi-and supercentenarians, could
provide important information about their ability to adapt to factors associated with immune …

Human Cytomegalovirus (HCMV) is an immensely pervasive herpesvirus, persistently
infecting high percentages of the world population. Despite the apparent robust host …