Lipotoxicity and the gut-liver axis in NASH pathogenesis

F Marra, G Svegliati-Baroni - Journal of hepatology, 2018 - Elsevier
The pathogenesis of non-alcoholic fatty liver disease, particularly the mechanisms whereby
a minority of patients develop a more severe phenotype characterised by hepatocellular …

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

M Mota, BA Banini, SC Cazanave, AJ Sanyal - Metabolism, 2016 - Elsevier
The exposure of hepatocytes to high concentrations of lipids and carbohydrates and the
ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A …

[HTML][HTML] A multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation

A Schlegel, M Mueller, X Muller, J Eden… - Journal of …, 2023 - Elsevier
Background & Aims Machine perfusion is a novel method intended to optimize livers before
transplantation. However, its effect on morbidity within a 1-year period after transplantation …

Health implications of high dietary omega‐6 polyunsaturated fatty acids

E Patterson, R Wall, GF Fitzgerald… - Journal of nutrition …, 2012 - Wiley Online Library
Omega‐6 (n‐6) polyunsaturated fatty acids (PUFA)(eg, arachidonic acid (AA)) and omega‐3
(n‐3) PUFA (eg, eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator …

Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: A clinical review

M Bagherniya, V Nobili, CN Blesso… - Pharmacological research, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver diseases, and is closely
related to metabolic syndrome and its related conditions, diabetes mellitus and dyslipidemia …

Nonalcoholic fatty liver disease: pathology and pathogenesis

DG Tiniakos, MB Vos, EM Brunt - Annual Review of Pathology …, 2010 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is recognized as the leading cause of chronic liver
disease in adults and children. NAFLD encompasses a spectrum of liver injuries ranging …

New aspects of lipotoxicity in nonalcoholic steatohepatitis

N Mendez-Sanchez, VC Cruz-Ramon… - International journal of …, 2018 - mdpi.com
NASH is becoming increasingly common worldwide because of the growing global
prevalence of obesity and consequently NAFLD. Unfortunately, the mechanism of …

Fatty acid composition analyses of commercially important fish species from the Pearl River Estuary, China

X Zhang, X Ning, X He, X Sun, X Yu, Y Cheng, RQ Yu… - PLoS …, 2020 - journals.plos.org
Evaluation of fish nutritional content information could provide essential guidance for
seafood consumption and human health protection. This study investigated the lipid …

[HTML][HTML] Modulation of hepatic steatosis by dietary fatty acids

A Ferramosca, V Zara - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) describes a range of conditions caused by fat
deposition within liver cells. Liver fat content reflects the equilibrium between several …

[HTML][HTML] Liver transplantation using fatty livers: always feasible?

L McCormack, P Dutkowski, AM El-Badry… - Journal of hepatology, 2011 - Elsevier
Steatotic liver grafts represent the most common type of “extended criteria” organs that have
been introduced during the last two decades due to the disparity between liver transplant …