RATIONALE: Increasing attention is being given to the evaluation of public health
interventions. Methods for the economic evaluation of clinical interventions are well …

Background. Microsimulation models (MSMs) for health outcomes simulate individual event
histories associated with key components of a disease process; these simulated life histories …

Health technology assessment (HTA) is a dynamic, rapidly evolving process, embracing
different types of assessments that inform real-world decisions about the value (ie, benefits …

This paper describes the key principles of why an assessment of uncertainty and its
consequences are critical for the types of decisions that a body such as the UK National …

Health economic evaluations have recently become an important part of the clinical and
medical research process and have built upon more advanced statistical decision-theoretic …

The past few years have seen rapid changes in the methods of decision-analytic modelling
of healthcare programmes for the purposes of economic evaluation. This paper focuses on …

Accounting for uncertainty is now a standard part of decision-analytic modeling and is
recommended by many health technology agencies and published guidelines. However, the …

Health economics is a relatively new discipline, essentially characterised by the integration
of different expertise and perspectives. Clearly, the clinical aspect is fundamental and the …

Although probabilistic analysis has become the accepted standard for decision analytic cost-
effectiveness models, deterministic one-way sensitivity analysis continues to be used to …

Parameter uncertainty, patient heterogeneity, and stochastic uncertainty of outcomes are
increasingly important concepts in medical decision models. The purpose of this study is to …