Epidemiological studies identify midlife hearing loss as an independent risk factor for
dementia, estimated to account for 9% of cases. We evaluate candidate brain bases for this …

The association between hearing impairment and dementia has emerged as a major public
health challenge, with significant opportunities for earlier diagnosis, treatment and …

A variety of cognitive disorders are worsened by stress exposure and involve dysfunction of
the newly evolved prefrontal cortex (PFC). Exposure to acute, uncontrollable stress …

Objective To examine region‐and substrate‐specific autoradiographic and in vitro binding
patterns of positron emission tomography tracer [F‐18]‐AV‐1451 (previously known as …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …

Eighty-three brains obtained at autopsy from nondemented and demented individuals were
examined for extracellular amyloid deposits and intraneuronal neurofibrillary changes. The …

We present here both linear regressions and multivariate analyses correlating three global
neuropsychological tests with a number of structural and neurochemical measurements …

This report describes the first human study of a novel amyloid‐imaging positron emission
tomography (PET) tracer, termed Pittsburgh Compound‐B (PIB), in 16 patients with …

We studied the accumulation of neurofibrillary tangles (NFTs) and senile plaques (SPs) in
10 Alzheimer's disease patients who had been examined during life. We counted NFTs and …